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1920 S. Kingshighway Blvd.
St. Louis, MO 63110

Sigma-Aldrich Manufacturing Plant

McGrath & Associates teamed with design firm CE&IC to complete an expansion of one of Sigma-Aldrich Corporation’s facilities in St. Louis designed to support its custom manufacturing services business unit, SAFC® Commercial (

In St. Louis, SAFC is investing in commercial-scale manufacturing capacity for Antibody Drug Conjugates (ADCs).  ADC technologies have shown exceptional promise in targeted therapies for chronic diseases such as cancer.

The expansion will complement the Company’s existing clinical ADC manufacturing suite.  The updated facility features segregated areas for high-potent solids handling and manufacturing and aseptic bulk filling of product.  The project design included additional commercial-scale manufacturing capacity to seamlessly accommodate future increases in demand for ADC production.

The St. Louis expansion will enable continuous scale-up of ADCs, from preclinical to clinical phases and into commercial-scale production.

Work Performed

Construction Manager
General Contractor

Project Partners